Ionic permeabilities of the human red blood cell: insights of a simple mathematical model
Stéphane Égée1 ; Marie Postel2 ; Benoît Sarels2
1 Sorbonne Université, CNRS, Laboratory of Integrative Biology of Marine Models (LBI2M), Station Biologique de Roscoff (SBR), F-29688 Roscoff, France
2 Sorbonne Université, CNRS, Université Paris Cité, Laboratoire Jacques-Louis Lions (LJLL), F-75005 Paris, France
MathematicS In Action, Tome 13 (2024) no. 1, pp. 1-31.

We are interested in the system of ion channels present at the membrane of the human red blood cell. The cell, under specific experimental circumstances, presents important variations of its membrane potential coupled to variations of the main ions’ concentration ensuring its homeostasis.

In this collaborative work between biologists and mathematicians a simple mathematical model is designed to explain experimental measurements of membrane potential and ion concentrations. Its construction is presented, as well as illustrative simulations and a calibration of the model on real data measurements. A sensitivity analysis of the model parameters is performed. The impact of blood sample storage on ion permeabilities is discussed.

Publié le :
DOI : 10.5802/msia.39
Classification : 00X99
Mots-clés : Red blood cell, erythrocytes, ions transfer, permeability, ODE model, calibration
Stéphane Égée 1 ; Marie Postel 2 ; Benoît Sarels 2

1 Sorbonne Université, CNRS, Laboratory of Integrative Biology of Marine Models (LBI2M), Station Biologique de Roscoff (SBR), F-29688 Roscoff, France
2 Sorbonne Université, CNRS, Université Paris Cité, Laboratoire Jacques-Louis Lions (LJLL), F-75005 Paris, France
Licence : CC-BY 4.0
Droits d'auteur : Les auteurs conservent leurs droits 
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Stéphane Égée; Marie Postel; Benoît Sarels. Ionic permeabilities of the human red blood cell: insights of a simple mathematical model. MathematicS In Action, Tome 13 (2024) no. 1, pp. 1-31. doi : 10.5802/msia.39. https://msia.centre-mersenne.org/articles/10.5802/msia.39/

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