Mathematical Homogenization in the Modelling of Digestion in the Small Intestine
MathematicS In Action, Tome 6 (2013) no. 1, pp. 1-19

Digestion in the small intestine is the result of complex mechanical and biological phenomena which can be modelled at different scales. In a previous article, we introduced a system of ordinary differential equations for describing the transport and degradation-absorption processes during the digestion. The present article sustains this simplified model by showing that it can be seen as a macroscopic version of more realistic models including biological phenomena at lower scales. In other words, our simplified model can be considered as a limit of more realistic ones by averaging-homogenization methods on biological processes representation.

Publié le :
DOI : 10.5802/msia.7
Classification : 92A09, 35B27, 34C29, 49L25
Keywords: Digestion in the small intestine, peristalsis, intestinal villi, homogenization, viscosity solutions

Masoomeh Taghipoor  1 , 2   ; Guy Barles  2   ; Christine Georgelin  2   ; Jean-René Licois  2   ; Philippe Lescoat  1

1 INRA, UR83 Recherches Avicoles, 37380 Nouzilly, France.
2 Laboratoire de Mathématiques et Physique Théorique (UMR CNRS 7350). Fédération Denis Poisson (FR CNRS 2964) Université de Tours. Faculté des Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
Masoomeh Taghipoor; Guy Barles; Christine Georgelin; Jean-René Licois; Philippe Lescoat. Mathematical Homogenization in the Modelling of Digestion in the Small Intestine. MathematicS In Action, Tome 6 (2013) no. 1, pp. 1-19. doi: 10.5802/msia.7
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[1] G. Barles Solutions de viscosité des équations de Hamilton-Jacobi, Mathématiques & Applications (Berlin) [Mathematics & Applications], 17, Springer-Verlag, Paris, 1994 | Zbl

[2] G. Barles Nonlinear Neumann boundary conditions for quasilinear degenerate elliptic equations and applications, J. Differential Equations, Volume 154 (1999) no. 1, pp. 191-224 | Zbl | MR | DOI

[3] G. Barles; F. Da Lio; P.-L. Lions; P. E. Souganidis Ergodic problems and periodic homogenization for fully nonlinear equations in half-space type domains with Neumann boundary conditions, Indiana Univ. Math. J., Volume 57 (2008) no. 5, pp. 2355-2375 | Zbl | MR | DOI

[4] M. G. Crandall; H. Ishii; P.-L. Lions User’s guide to viscosity solutions of second order partial differential equations, Bull. Amer. Math. Soc. (N.S.), Volume 27 (1992) no. 1, pp. 1-67 | Zbl | MR | DOI

[5] L. C. Evans The perturbed test function method for viscosity solutions of nonlinear PDE, Proc. Roy. Soc. Edinburgh Sect. A, Volume 111 (1989) no. 3-4, pp. 359-375 | Zbl | MR | DOI

[6] L. C. Evans Periodic homogenisation of certain fully nonlinear partial differential equations, Proc. Roy. Soc. Edinburgh Sect. A, Volume 120 (1992) no. 3-4, pp. 245-265 | Zbl | MR | DOI

[7] H. Ishii Perron’s method for Hamilton-Jacobi equations, Duke Math. J., Volume 55 (1987) no. 2, pp. 369-384 | Zbl | MR | DOI

[8] J. Keener; J. Sneyd Mathematical physiology. Vol. II: Systems physiology, Interdisciplinary Applied Mathematics, 8/, Springer, New York, 2009 | MR | Zbl | DOI

[9] J. D. Logan; A. Joern; W. Wolesensky Location, time, and temperature dependence of digestion in simple animal tracts, J. Theoret. Biol., Volume 216 (2002) no. 1, pp. 5-18 | MR | DOI

[10] A. V. Mernone; J. N. Mazumdar; S. K. Lucas A mathematical study of peristaltic transport of a Casson fluid, Math. Comput. Modelling, Volume 35 (2002) no. 7-8, pp. 895-912 | MR | Zbl | DOI

[11] R. Miftahof; N. Akhmadeev Dynamics of intestinal propulsion, J. Theoret. Biol., Volume 246 (2007) no. 2, pp. 377-393 | Zbl | MR | DOI

[12] L. C. Piccinini Homogeneization problems for ordinary differential equations, Rend. Circ. Mat. Palermo (2), Volume 27 (1978) no. 1, pp. 95-112 | Zbl | MR | DOI

[13] D. Randall; W. Burggren; K. French; R. Eckert Eckert Animal Physiology: Mechanisms and Adaptations, W.H. Freeman & Company, 1997 http://amazon.com/o/ASIN/0716724146/

[14] J. Rivest; J. F. Bernier; C. Pomar A dynamic model of protein digestion in the small intestine of pigs, J Anim Sci, Volume 78 (2000) no. 2, pp. 328-340 | DOI

[15] M. Taghipoor; P. Lescoat; J.-R. Licois; Ch. Georgelin; G. Barles Mathematical modeling of transport and degradation of feedstuffs in the small intestine, Journal of Theoretical Biology, Volume 294 (2012), pp. 114 -121 http://www.sciencedirect.com/science/article/pii/S002251931100539X | Zbl | DOI

[16] K.E. Yamauchi Review of a histological intestinal approach to assessing the intestinal function in chickens and pigs, Animal Science Journal, Volume 78 (2007), pp. 356-370 | DOI

[17] X. T. Zhao; M. A. McCamish; R. H. Miller; L. Wang; H. C. Lin Intestinal transit and absorption of soy protein in dogs depend on load and degree of protein hydrolysis., J Nutr, Volume 127 (1997) no. 12, pp. 2350-2356 | DOI

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