Moran model with simultaneous strong and weak selections: convergence towards a Λ-Wright–Fisher SDE
François G. Ged1
1 Chair of Statistical Field Theory, École Polytechnique Fédérale de Lausanne, Switzerland
MathematicS In Action, Maths Bio, Tome 12 (2023) no. 1, pp. 87-116.

We establish a connection between two population models by showing that one is the scaling limit of the other, as the population grows large. In the infinite population model, individuals are split into two subpopulations, carrying either a selective advantageous allele, or a disadvantageous one. The proportion of disadvantaged individuals in the population evolves according to the Λ-Wright–Fisher stochastic differential equation (SDE) with selection, and the genealogy is described by the so-called Bolthausen–Sznitman coalescent. This equation has appeared in the Λ-lookdown model with selection studied by Bah and Pardoux [1]. Schweinsberg in [16] showed that in a specific setting, due to the strong selection, the genealogy of the so-called Moran model with selection converges to the Bolthausen–Sznitman coalescent. By splitting the population into two adversarial subgroups and adding a weak selection mechanism, we show that the proportion of disadvantaged individuals in the Moran model with strong and weak selections converges to the solution of the Λ-Wright–Fisher SDE of [1].

Publié le :
DOI : 10.5802/msia.33
Classification : 60J80, 92D15, 92D25, 60H10
Mots-clés : Moran model with selection, Bolthausen–Sznitman’s coalescent, $\Lambda $-Wright–Fisher SDE
François G. Ged 1

1 Chair of Statistical Field Theory, École Polytechnique Fédérale de Lausanne, Switzerland
Licence : CC-BY 4.0
Droits d'auteur : Les auteurs conservent leurs droits 
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François G. Ged. Moran model with simultaneous strong and weak selections: convergence towards a $\Lambda $-Wright–Fisher SDE. MathematicS In Action, Maths Bio, Tome 12 (2023) no. 1, pp. 87-116. doi : 10.5802/msia.33. https://msia.centre-mersenne.org/articles/10.5802/msia.33/

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